Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745597 | 0.89 | KDM5B (0.53) | ALDH1A1KDM5BCCNKCDK12KMT2A | |
| SCHEMBL3864624 | 0.89 | KDM5B (0.53) | ALDH1A1KDM5BCCNKCDK12KMT2A | |
| SCHEMBL3865252 | 0.87 | GSK3B (0.47) | ALDH1A1KDM5BCCNKCDK12KDM5A | |
| SCHEMBL5748442 | 0.87 | GSK3B (0.47) | ALDH1A1KDM5BCCNKCDK12KDM5A | |
| SCHEMBL3856209 | 0.86 | LMNA (0.42) | ALDH1A1KDM5BCCNKCDK12KMT2A | |
| SCHEMBL5750443 | 0.86 | LMNA (0.42) | ALDH1A1KDM5BCCNKCDK12KMT2A | |
| SCHEMBL5747668 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KDM5BCCNKCDK12KMT2A | |
| SCHEMBL3862802 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KDM5BCCNKCDK12KMT2A | |
| SCHEMBL3858635 | 0.85 | EPHX1 (0.51) | EPHX1ALDH1A1 | |
| SCHEMBL3862788 | 0.85 | KMT2A (0.46) | EPHX2EPHX1ALDH1A1KDM5BCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680415-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2006-07-19 | — | — | EP | claimed |
| WO-2005035524-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENSIS INHIBITORS | ABBOTT LABORATORIES (US) | 2005-04-21 | — | — | WO | claimed |