SCHEMBL5748818

SCHEMBL5748818

CCc1c(N)ccc2cc3ccccc3cc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.42
HTR2A P28223 2/20 0.42
CYP2A6 P11509 1/20 0.42
ALDH1A1 P00352 8/20 0.41
HSD17B10 Q99714 5/20 0.41
CYP3A4 P08684 3/20 0.41
HIF1A Q16665 2/20 0.41
ALOX15 P16050 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
HBB P68871 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CYP1B1 Q16678 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
GAA P10253 4/20 0.37
KDM4E B2RXH2 3/20 0.37
ERBB2 P04626 1/20 0.36
FYN P06241 1/20 0.36
MAOA P21397 1/20 0.36
ACHE P22303 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1161044 0.82 ALDH1A1 (0.46) CYP1A2HTR2ACYP2A6ALDH1A1HSD17B10
SCHEMBL5748132 0.80 TLR8 (0.44) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL5748781 0.80 TLR8 (0.44) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL5747992 0.80 TLR8 (0.44) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL16267147 0.80 CYP2A6 (0.46) CYP1A2HTR2ACYP2A6ALDH1A1HSD17B10
SCHEMBL9137780 0.79 CYP1A2 (0.44) CYP1A2HTR2ACYP2A6ALDH1A1HSD17B10
SCHEMBL27677260 0.78 CYP1A2 (0.42) CYP1A2HTR2ACYP2A6ALDH1A1HSD17B10
SCHEMBL5750812 0.76 HTR2A (0.50) CYP1A2HTR2ACYP2A6ALDH1A1HSD17B10
SCHEMBL5750973 0.75 HTR2A (0.48) CYP1A2HTR2AALDH1A1HSD17B10CYP3A4
SCHEMBL20274127 0.75 ALDH1A1 (0.46) CYP1A2HTR2ACYP2A6ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293503-A1 Polyaminopyridines and method for producing same SUMITOMO SEIKA CHEMICALS CO., LTD (JP) 2006-12-28 US disclosed
EP-1669390-A1 POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2006-06-14 EP disclosed