Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SDHB | P21912 | 7/20 | 0.41 |
| ▸ | BPTF | Q12830 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.39 |
| ▸ | STAT3 | P40763 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | STAT1 | P42224 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8467175 | 0.99 | HTR1B (0.63) | HTR1BHTR2BGPR65LMNAKDM4E | |
| SCHEMBL5745041 | 0.83 | HTR1B (0.45) | HTR1BHTR2BGPR65LMNAKDM4E | |
| SCHEMBL5749062 | 0.81 | HTR1B (0.60) | HTR1BHTR2BGPR65ALOX5APFEN1 | |
| SCHEMBL5746388 | 0.81 | HTR1B (0.64) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| SCHEMBL18461518 | 0.80 | HTR1B (0.72) | HTR1BHTR2BGPR65ALOX5APFEN1 | |
| SCHEMBL5749278 | 0.80 | LMNA (0.53) | HTR1BHTR2BGPR65LMNAKDM4E | |
| SCHEMBL8382821 | 0.79 | HTR1B (0.71) | HTR1BHTR2BGPR65ALOX5APFEN1 | |
| SCHEMBL375979 | 0.79 | HTR1B (1.00) | HTR1BHTR2BGPR65ALOX5APFEN1 | |
| SCHEMBL5751060 | 0.78 | HTR1B (0.41) | HTR1BHTR2BGPR65LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL5746097 | 0.77 | HTR1B (0.97) | HTR1BHTR2BGPR65ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901474-B1 | ARYL PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-04-19 | — | — | EP | disclosed |
| EP-1321169-A1 | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament | Biofrontera Pharmaceuticals AG (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-5958934-A | 5-HT 2B ANTAGONIST | SYNTEX (U.S.A.) INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5952331-A | SELECTIVE 5HT2B ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONIST; TREATING DISORDERS OF THE GASTROINTESTINAL TRACK, RESTENOSIS, ASTHMA AND OBSTRUCTIVE AIRWAY DISEASE, PROSTATIC HYPERPLASIA, GENERALIZED ANXIETY, PANIC DISORDER | SYNTEX (USA) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0901474-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5863924-A | Aryl pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997044326-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-27 | — | — | WO | disclosed |