Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.51 |
| ▸ | GRM5 | P41594 | 9/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 2/20 | 0.44 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4879856 | 0.93 | HTR6 (0.56) | HTR6GRM1GRM5PDK4JAK1 | |
| SCHEMBL5750065 | 0.92 | ELANE (0.45) | JAK1 | |
| SCHEMBL31025087 | 0.82 | PDK4 (0.54) | HTR6GRM1GRM5PDK4JAK1 | |
| SCHEMBL25571069 | 0.82 | PDK4 (0.54) | HTR6GRM1GRM5PDK4JAK1 | |
| SCHEMBL12874666 | 0.81 | GRM1 (0.49) | HTR6GRM1GRM5PDK4PDE10A | |
| SCHEMBL17655532 | 0.80 | PDK4 (0.61) | HTR6GRM1GRM5PDK4PDE10A | |
| SCHEMBL19092559 | 0.79 | PDK4 (0.58) | HTR6GRM1GRM5PDK4PDE10A | |
| SCHEMBL38663138 | 0.79 | PDK4 (0.55) | HTR6GRM1GRM5PDK4JAK1 | |
| SCHEMBL4064267 | 0.79 | CES2 (0.43) | JAK1 | |
| SCHEMBL23716616 | 0.79 | GRM5 (0.53) | HTR6GRM1GRM5PDK4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497292-B1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-06-14 | — | — | EP | disclosed |
| EP-1497292-A1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003082867-A1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2003-10-09 | — | — | WO | disclosed |