Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27754688 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDKDM4ELMNAHTT | |
| SCHEMBL27734620 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDKDM4ELMNAHTT | |
| SCHEMBL5747494 | 0.90 | CXCR3 (0.47) | HSD11B1SMN1; SMN2HPGDKDM4ELMNA | |
| SCHEMBL5746954 | 0.88 | NR1H2 (0.47) | SMN1; SMN2HPGDNR1H2NR1H3KDM4E | |
| SCHEMBL6354804 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDKDM4ELMNAHTT | |
| SCHEMBL5748046 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDKDM4ELMNAHTT | |
| SCHEMBL5746828 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDKDM4ELMNAHTT | |
| SCHEMBL5487074 | 0.84 | KDM4E (0.59) | SMN1; SMN2HPGDKDM4ELMNAHTT | |
| SCHEMBL5795980 | 0.84 | CXCR3 (0.48) | NR1H2NR1H3KDM4EF13A1TGM2 | |
| SCHEMBL5778752 | 0.82 | NR1H2 (0.40) | SMN1; SMN2HPGDNR1H2NR1H3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735280-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | Kalypsys, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115983-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | KALYPSYS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |