Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749676 | 0.80 | HPGD (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL4029525 | 0.80 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5750358 | 0.77 | KIF11 (0.42) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5144677 | 0.77 | PDE4A (0.49) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5555021 | 0.77 | PDE4A (0.49) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5738140 | 0.77 | PDE4B (0.69) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5784852 | 0.77 | PDE4A (0.49) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL4028286 | 0.77 | MEN1 (0.46) | MEN1KMT2APABPC1EIF4HRAD52 | |
| SCHEMBL5740040 | 0.76 | MEN1 (0.41) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5144517 | 0.74 | KIF11 (0.45) | MEN1KMT2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551812-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-01-04 | — | — | EP | disclosed |
| EP-1551812-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2003049678-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-06-19 | — | — | WO | disclosed |