Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739886 | 0.80 | PDE4A (0.58) | KIF11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5142309 | 0.80 | KIF11 (0.48) | KIF11HDAC1HDAC6PDE4APDE4B | |
| SCHEMBL5555712 | 0.80 | KIF11 (0.46) | KIF11HDAC1HDAC6PDE4APDE4B | |
| SCHEMBL5144764 | 0.80 | KIF11 (0.51) | KIF11HDAC1HDAC6PDE4APDE4B | |
| SCHEMBL5739410 | 0.80 | KIF11 (0.43) | KIF11HDAC1HDAC6PDE4APDE4B | |
| SCHEMBL5739778 | 0.80 | KIF11 (0.42) | KIF11HDAC1HDAC6PDE4APDE4B | |
| SCHEMBL4027441 | 0.79 | KIF11 (0.62) | KIF11 | |
| SCHEMBL5749679 | 0.77 | MEN1 (0.46) | PDE4APDE4BPDE4CPDE4DHRH3 | |
| SCHEMBL5739539 | 0.77 | KIF11 (0.50) | KIF11HDAC1HDAC6PDE4APDE4B | |
| SCHEMBL13911479 | 0.77 | KIF11 (0.62) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551812-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-01-04 | — | — | EP | claimed |
| EP-1551812-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2003049678-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-06-19 | — | — | WO | claimed |
| EP-1551812-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-01-04 | — | — | EP | disclosed |
| EP-1551812-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2003049678-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-06-19 | — | — | WO | disclosed |