Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HRAS | P01112 | 6/20 | 0.49 |
| ▸ | ESR1 | P03372 | 6/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19614897 | 0.89 | HRAS (0.52) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL2398688 | 0.88 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL14355720 | 0.88 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL18089498 | 0.88 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HRASESR1 | |
| Hydrochloric Acid SCHEMBL10691985 | 0.87 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL5750249 | 0.87 | HRAS (0.66) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL5750242 | 0.87 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL10691569 | 0.86 | HDAC1 (0.55) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL10691121 | 0.86 | HDAC1 (0.55) | HDAC1HDAC2HDAC8HRASESR1 | |
| SCHEMBL13288102 | 0.86 | HDAC1 (0.64) | HDAC1HDAC2HDAC8HRASESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191372-A1 | Dna-targeted benzotriazine 1,4-dioxides and their use in cancer therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191372-A1 | Dna-targeted benzotriazine 1,4-dioxides and their use in cancer therapy | HIF1AN, HIF1A, HYOU1 | HDAC1 1200/4885HDAC2 698/4885HDAC8 1057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.