Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.72 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12354487 | 0.84 | RET (1.00) | RETHTR7KDM4ESMN1; SMN2HTR2A | |
| SCHEMBL5746909 | 0.82 | RET (0.50) | RETSLC22A2SLC22A3KDM4ESMN1; SMN2 | |
| SCHEMBL30729415 | 0.81 | RET (0.66) | RETHTR7ADRB2ADRB1SLC22A2 | |
| SCHEMBL5749933 | 0.75 | HTR2A (0.48) | RETGPR3KDM4EALDH1A1HTR2A | |
| SCHEMBL27418159 | 0.75 | RET (0.41) | RETGPR3SLC22A2SLC22A3ALDH1A1 | |
| SCHEMBL5745828 | 0.74 | HTR1B (0.44) | RETGPR3KDM4ESMN1; SMN2HTR2A | |
| SCHEMBL10447563 | 0.74 | ACHE (0.46) | RETGPR3SLC22A2SLC22A3HTR2A | |
| SCHEMBL5748202 | 0.72 | HTR2A (0.45) | RETHTR2AHRH1CHRM2ADRA2A | |
| SCHEMBL5749108 | 0.71 | ADRB2 (0.51) | RETHTR7ADRB2KDM4EHTR2A | |
| SCHEMBL5747939 | 0.71 | HTR1B (0.49) | RETKDM4ESMN1; SMN2HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |