Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.48 |
| ▸ | TYMS | P04818 | 3/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750124 | 0.85 | L3MBTL1 (0.47) | HCAR2 | |
| SCHEMBL28835744 | 0.71 | HCAR2 (0.65) | HCAR2 | |
| SCHEMBL5752981 | 0.69 | MARS1 (0.34) | TYMSDHFR | |
| SCHEMBL3085155 | 0.66 | HCAR2 (1.00) | HCAR2 | |
| SCHEMBL28628018 | 0.66 | HCAR2 (0.67) | HCAR2 | |
| SCHEMBL17224976 | 0.65 | HCAR2 (0.70) | HCAR2 | |
| SCHEMBL3131871 | 0.65 | HCAR2 (1.00) | HCAR2 | |
| SCHEMBL16240034 | 0.63 | — | — | |
| SCHEMBL21582145 | 0.63 | HCAR2 (0.43) | HCAR2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5752055 | 0.63 | SLC22A12 (0.35) | TYMSDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299361-B1 | PYRAZOLE DERIVATIVES | PFIZER LTD (GB) | 2006-07-19 | — | — | EP | claimed |