Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889840 | 0.86 | CHRNB2 (0.44) | CHRNB2CHRNA5CHRNA4GRM5ALDH1A1 | |
| SCHEMBL2890137 | 0.86 | CHRNB2 (0.44) | CHRNB2CHRNA5CHRNA4GRM5PSEN1 | |
| SCHEMBL2889873 | 0.85 | CHRNB2 (0.44) | CHRNB2CHRNA5CHRNA4GRM5PSEN1 | |
| SCHEMBL2891576 | 0.77 | CHRNB2 (0.43) | CHRNB2CHRNA5CHRNA4GRM5PSEN1 | |
| SCHEMBL2896306 | 0.76 | PSEN1 (0.43) | CHRNB2CHRNA5CHRNA4GRM5PSEN1 | |
| SCHEMBL2897493 | 0.76 | CHRNB2 (0.45) | CHRNB2CHRNA5CHRNA4GRM5ALDH1A1 | |
| SCHEMBL2889468 | 0.76 | GRM5 (0.45) | GRM5ALDH1A1 | |
| SCHEMBL5823300 | 0.75 | CHRNB2 (0.43) | CHRNB2CHRNA5CHRNA4GRM5ALDH1A1 | |
| SCHEMBL2889466 | 0.75 | CHRNB2 (0.43) | CHRNB2CHRNA5CHRNA4GRM5ALDH1A1 | |
| SCHEMBL2893245 | 0.75 | ALDH1A1 (0.36) | GRM5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |