Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5782757 | 0.92 | PDE4B (0.41) | PDE4BADORA2AACHEBACE1PARP1 | |
| SCHEMBL4050977 | 0.92 | ADORA2A (0.48) | PDE4BADORA2AACHEBACE1PARP1 | |
| SCHEMBL4052611 | 0.91 | PDE4B (0.55) | PDE4BADORA2ATDP1MAPTADORA1 | |
| SCHEMBL4050693 | 0.84 | PDE4B (0.43) | PDE4BADORA2AMAPTADORA1ALDH1A1 | |
| SCHEMBL4049559 | 0.81 | PDE4B (0.44) | PDE4BACHEBACE1MAPTADORA1 | |
| SCHEMBL4054494 | 0.81 | PDE4B (0.56) | PDE4BADORA2AACHEBACE1TDP1 | |
| SCHEMBL5747425 | 0.79 | PDE4B (0.42) | PDE4BMAPTADORA1L3MBTL1ALDH1A1 | |
| SCHEMBL4706084 | 0.78 | PDE4B (0.62) | PDE4BADORA2AACHEBACE1PARP1 | |
| SCHEMBL4709069 | 0.78 | PDE4B (0.62) | PDE4BACHEBACE1PARP1PDE4A | |
| SCHEMBL5753107 | 0.78 | PDE4B (0.39) | PDE4BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | disclosed |