Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.37 |
| ▸ | GPR3 | P46089 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752905 | 0.92 | CRHR1 (0.53) | CRHR1SCN9ARUNX1GPR3CHRM5 | |
| SCHEMBL5751614 | 0.81 | CRHR1 (0.58) | CRHR1SCN9ARUNX1GPR3 | |
| SCHEMBL6286387 | 0.81 | CRHR1 (0.61) | CRHR1SCN9ARUNX1GPR3 | |
| SCHEMBL5751665 | 0.80 | CRHR1 (0.45) | CRHR1SCN9ARUNX1GPR3CTSA | |
| SCHEMBL5414869 | 0.79 | CRHR1 (0.68) | CRHR1SCN9ARUNX1GPR3CTSA | |
| SCHEMBL5752597 | 0.79 | CRHR1 (0.53) | CRHR1SCN9ARUNX1GPR3CTSA | |
| SCHEMBL5441650 | 0.77 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL4878160 | 0.76 | CRHR1 (0.53) | CRHR1SCN9ARUNX1GPR3CTSA | |
| SCHEMBL5751947 | 0.75 | CRHR1 (0.49) | CRHR1SCN9ARUNX1CTSA | |
| SCHEMBL14619741 | 0.74 | CRHR1 (0.54) | CRHR1SCN9ARUNX1GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060199823-A1 | Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands | NEUROGEN CORPORATION (US) | 2006-09-07 | — | — | US | disclosed |
| EP-1680424-A2 | HETEROARYL FUSED PYRIDINES, PYRAZINES AND PYRIMIDINES AS CRF1 RECEPTOR LIGANDS | Neurogen Corporation (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050113379-A1 | Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands | AVENTIS PHARMACEUTICALS, INC. | 2005-05-26 | — | — | US | disclosed |
| WO-2005023806-A2 | HETEROARYL FUSED PYRIDINES, PYRAZINES AND PYRIMIDINES AS CRF1 RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199823-A1 | Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands | CRHR1, CRHR2, HTR5A | CRHR1 1/4885SCN9A 4767/4885RUNX1 1387/4885 |
| US-20050113379-A1 | Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands | CRHR1, CRHR2, HTR5A | CRHR1 1/4885SCN9A 4767/4885RUNX1 1387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.