Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895652 | 0.78 | NFE2L2 (0.38) | RXRAGRIN1GRIN2BPTGS1PTGS2 | |
| SCHEMBL2895653 | 0.78 | NFE2L2 (0.38) | RXRAGRIN1GRIN2BPTGS1PTGS2 | |
| SCHEMBL2889986 | 0.74 | NFE2L2 (0.37) | PTGS2CASP3SENP8SENP7SENP6 | |
| SCHEMBL2897293 | 0.73 | GRM5 (0.46) | CASP3SENP8SENP7SENP6ALDH1A1 | |
| SCHEMBL2897290 | 0.73 | GRM5 (0.46) | CASP3SENP8SENP7SENP6ALDH1A1 | |
| SCHEMBL2889795 | 0.68 | GRM5 (0.46) | ALDH1A1KMT2AKDM4EHPGDMEN1 | |
| SCHEMBL2897163 | 0.68 | APP (0.39) | ALDH1A1KMT2AKDM4EHPGDMEN1 | |
| SCHEMBL2889796 | 0.68 | GRM5 (0.46) | ALDH1A1KMT2AKDM4EHPGDMEN1 | |
| SCHEMBL7086147 | 0.67 | NFE2L2 (0.57) | TTRALOX5PTGS1PTGS2NFE2L2 | |
| SCHEMBL2895892 | 0.65 | GRM5 (0.53) | ALDH1A1KDM4ETSHRGRM5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |