Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756383 | 0.79 | NQO2 (0.47) | KMT2AOPRK1ALDH1A1AMY1AMEN1 | |
| SCHEMBL29532414 | 0.72 | KMT2A (0.67) | KMT2AOPRK1ALDH1A1MEN1ACHE | |
| SCHEMBL2263219 | 0.72 | KMT2A (0.67) | KMT2AOPRK1ALDH1A1MEN1ACHE | |
| SCHEMBL5754517 | 0.71 | KMT2A (0.38) | KMT2AOPRK1ALDH1A1MEN1KDM4E | |
| SCHEMBL12328353 | 0.68 | ERN1 (0.46) | KMT2AERN1ALDH1A1AMY1AMEN1 | |
| SCHEMBL4113627 | 0.68 | KMT2A (0.43) | KMT2AOPRK1ALDH1A1MEN1MAPT | |
| SCHEMBL28133331 | 0.68 | KMT2A (0.60) | KMT2AOPRK1ERN1PTPN1ALDH1A1 | |
| SCHEMBL3644484 | 0.67 | ALDH1A1 (0.67) | KMT2AERN1ALDH1A1AMY1AMEN1 | |
| SCHEMBL12104188 | 0.66 | GPR35 (0.49) | KMT2AERN1ALDH1A1MEN1KDM4E | |
| SCHEMBL8129389 | 0.66 | KMT2A (0.55) | KMT2AOPRK1ALDH1A1MEN1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218358-B1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| EP-1218358-A1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| US-6399603-B1 | QUINAZOLINES; RETARDING APOPTOSIS IN CELLS; INHIBITING CLEAVAGE OF PROTEIN SUBSTRATES BY CASPASE-3; CHEMICAL AND HYDROLYTIC STABILITY | ASTRAZENECA AB (SE) | 2002-06-04 | — | — | US | disclosed |
| WO-2001021598-A1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |