Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15266968 | 0.81 | CYP1A2 (0.48) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL5337507 | 0.80 | TUBB4A (0.50) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL27902298 | 0.80 | CYP2A6 (0.65) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL23458358 | 0.79 | CYP2A6 (0.50) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL29861952 | 0.79 | CYP2A6 (0.50) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL30503987 | 0.79 | CA12 (0.52) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL4194130 | 0.79 | CA12 (0.52) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL2171080 | 0.78 | CYP1A2 (0.48) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL3137389 | 0.78 | CYP2A6 (0.62) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 | |
| SCHEMBL12259995 | 0.78 | CYP2A6 (0.62) | CYP2A6CYP1A2HSD17B1HSD17B2RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084149-B2 | Naphthalene derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-08-01 | — | — | US | disclosed |
| EP-1073640-B1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA PHARMACEUTICAL (JP) | 2005-04-13 | — | — | EP | disclosed |
| US-20030236274-A1 | Naphthalene derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-12-25 | — | — | US | disclosed |
| US-6573289-B1 | Naphthalene derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-0934241-B1 | PRODUCTION OF 6-BROMO-2-METHOXYNAPHTHALENE AND DERIVATIVES | ALBEMARLE CORP (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-1073640-A1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054309-A1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-28 | — | — | WO | disclosed |
| EP-0934241-A1 | PRODUCTION OF 6-BROMO-2-METHOXYNAPHTHALENE AND DERIVATIVES | ALBEMARLE CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998011045-A1 | PRODUCTION OF 6-BROMO-2-METHOXYNAPHTHALENE AND DERIVATIVES | ALBEMARLE CORPORATION (US) | 1998-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236274-A1 | Naphthalene derivatives, their production and use | CYP17A1, CYP21A2, HSD17B1 | CYP2A6 108/4885CYP1A2 91/4885HSD17B1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.