Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.66 |
| ▸ | RB1 | P06400 | 7/20 | 0.62 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | CDC42 | P60953 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025335 | 0.85 | RB1 (0.60) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL13780949 | 0.85 | RB1 (0.60) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL13780953 | 0.84 | RB1 (0.58) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL4028219 | 0.83 | RB1 (0.57) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL16946171 | 0.83 | MAPT (0.75) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL5456610 | 0.83 | ALOX15 (1.00) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL15577169 | 0.83 | MAPT (0.75) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL4169472 | 0.83 | MAPT (0.75) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL275312 | 0.82 | SIRT1 (0.52) | MAPTALOX15MAPK1SMN1; SMN2SIRT1 | |
| SCHEMBL251128 | 0.80 | SIRT1 (1.00) | ALOX15SIRT1SIRT2RB1BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112094223-B | Ureido tetrahydrocarbazole small molecular organic compound and application thereof | 华东师范大学 | 2023-09-15 | — | — | CN | claimed |
| CN-112094223-A | Ureido-tetrahydrocarbazole micromolecule organic compound and application thereof | 华东师范大学 | 2020-12-18 | — | — | CN | claimed |
| CN-112094223-B | Ureido tetrahydrocarbazole small molecular organic compound and application thereof | 华东师范大学 | 2023-09-15 | — | — | CN | disclosed |
| CN-112094223-A | Ureido-tetrahydrocarbazole micromolecule organic compound and application thereof | 华东师范大学 | 2020-12-18 | — | — | CN | disclosed |
| CN-112094223-A | Ureido-tetrahydrocarbazole micromolecule organic compound and application thereof | 华东师范大学 | 2020-12-18 | — | — | CN | disclosed |
| CN-112094223-A | Ureido-tetrahydrocarbazole micromolecule organic compound and application thereof | 华东师范大学 | 2020-12-18 | — | — | CN | disclosed |
| EP-1646610-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SmithKline Beecham Corporation (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005386-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-20 | — | — | WO | disclosed |