Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 9/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752478 | 1.00 | PADI4 (0.44) | PADI4ARPRMT5WDR77ALDH1A1 | |
| SCHEMBL7505673 | 1.00 | PADI4 (0.44) | PADI4ARPRMT5WDR77ALDH1A1 | |
| SCHEMBL7502157 | 0.81 | CYP11B1 (0.51) | PADI4ALDH1A1SMN1; SMN2 | |
| SCHEMBL7502145 | 0.81 | CYP11B1 (0.51) | PADI4ALDH1A1SMN1; SMN2 | |
| SCHEMBL29214135 | 0.79 | ATM (0.51) | ARPRMT5ALDH1A1ATMNPSR1 | |
| SCHEMBL4832335 | 0.76 | PADI4 (0.44) | PADI4PARP1 | |
| SCHEMBL4834327 | 0.76 | PADI4 (0.44) | PADI4PARP1 | |
| SCHEMBL13053141 | 0.70 | CYP11B1 (0.55) | ALDH1A1SMN1; SMN2NPSR1TSHR | |
| SCHEMBL9000469 | 0.70 | GRM4 (0.39) | PADI4ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL4819165 | 0.70 | AR (0.51) | ARPRMT5WDR77ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165085-B1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2006-06-14 | — | — | EP | disclosed |