Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502157 | 1.00 | CYP11B1 (0.51) | CYP11B1CYP11B2CHEK1KMT2AMEN1 | |
| SCHEMBL29214135 | 0.85 | ATM (0.51) | CHEK1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5693205 | 0.82 | CHEK1 (0.62) | CYP11B1CYP11B2CHEK1KMT2AMEN1 | |
| SCHEMBL5693202 | 0.82 | CHEK1 (0.62) | CYP11B1CYP11B2CHEK1KMT2AMEN1 | |
| SCHEMBL5752477 | 0.81 | PADI4 (0.44) | ALDH1A1PADI4SMN1; SMN2 | |
| SCHEMBL5752478 | 0.81 | PADI4 (0.44) | ALDH1A1PADI4SMN1; SMN2 | |
| SCHEMBL7505673 | 0.81 | PADI4 (0.44) | ALDH1A1PADI4SMN1; SMN2 | |
| SCHEMBL4829935 | 0.74 | TDO2 (0.60) | CYP11B1CYP11B2KMT2AMEN1NPC1 | |
| SCHEMBL4832042 | 0.74 | TDO2 (0.60) | CYP11B1CYP11B2KMT2AMEN1NPC1 | |
| SCHEMBL12764197 | 0.74 | CHEK1 (0.62) | CYP11B1CYP11B2CHEK1CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165085-A1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | Novartis AG (CH) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059509-A1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2000-10-12 | — | — | WO | disclosed |