Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23538108 | 0.68 | EGFR (0.45) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL3781505 | 0.67 | DYRK1A (0.37) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL31662605 | 0.67 | NPC1 (0.47) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL31300632 | 0.67 | NPC1 (0.49) | NPC1PTGER4KMT2A | |
| SCHEMBL20604916 | 0.67 | NPC1 (0.49) | NPC1PTGER4KMT2A | |
| SCHEMBL1119311 | 0.67 | MPO (0.41) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL6259455 | 0.66 | NPC1 (0.42) | NPC1 | |
| SCHEMBL16023365 | 0.66 | NPC1 (0.42) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL29520372 | 0.66 | NPC1 (0.42) | NPC1 | |
| SCHEMBL26675951 | 0.65 | MAOA (0.40) | NPC1EGFRIGF1RSRCFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699762-A1 | 5-AMINO-4-HYDROXY-7-(1H-INDOLMETHYL)-8-METHYLNONAMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | Speedel Experimenta AG (CH) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005090305-A1 | 5-AMINO-4-HYDROXY-7-(1H-INDOLMETHYL)-8-METHYLNONAMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | SPEEDEL EXPERIMENTA AG (CH) | 2005-09-29 | — | — | WO | disclosed |