Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | GRK3 | P35626 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893486 | 0.89 | HDAC2 (0.48) | HDAC2PTK2ALDH1A1TP53HPGD | |
| SCHEMBL2893738 | 0.88 | ALDH1A1 (0.49) | HDAC2PTK2ALDH1A1TP53HPGD | |
| SCHEMBL20021735 | 0.72 | KMT2A (0.52) | HDAC2PTK2ALDH1A1TP53HPGD | |
| SCHEMBL20025649 | 0.71 | ALDH1A1 (0.52) | HDAC2PTK2ALDH1A1TP53HPGD | |
| SCHEMBL14476623 | 0.70 | KDM4E (0.39) | ALDH1A1HPGDLMNAKMT2AHSD17B10 | |
| SCHEMBL1544338 | 0.67 | KMT2A (0.50) | HDAC2PTK2ALDH1A1TP53HPGD | |
| SCHEMBL1544457 | 0.65 | GAA (0.48) | ALDH1A1KMT2ASMN1; SMN2CYP3A4TSHR | |
| SCHEMBL2898373 | 0.65 | GAA (0.45) | ALDH1A1HPGDLMNAKMT2AKDM4E | |
| SCHEMBL14281902 | 0.65 | SMN1; SMN2 (0.48) | HDAC2PTK2ALDH1A1LMNAHDAC1 | |
| SCHEMBL6246323 | 0.64 | SMN1; SMN2 (0.65) | HDAC2PTK2ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |