Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751605 | 0.87 | MAPK1 (0.59) | MAPK1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL25303817 | 0.85 | KMT2A (0.62) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12888865 | 0.85 | MAPK1 (0.65) | MAPK1NPC1RAB9ASMN1; SMN2MEN1 | |
| Acetic Acid SCHEMBL27641217 | 0.84 | KMT2A (0.60) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL28560551 | 0.83 | KDM4E (0.63) | SMN1; SMN2KMT2AKDM4EHSD17B10POLB | |
| SCHEMBL2845248 | 0.82 | MEN1 (0.55) | MAPK1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL12857834 | 0.82 | PYGM (0.57) | MEN1KMT2AKDM4EHSD17B10POLB | |
| SCHEMBL17037019 | 0.81 | MEN1 (0.71) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL28264707 | 0.81 | KDM4E (0.61) | SMN1; SMN2KMT2AKDM4EHSD17B10POLB | |
| SCHEMBL14338249 | 0.81 | MTNR1B (0.69) | MAPK1NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225894-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2006-07-05 | — | — | EP | disclosed |
| US-6730684-B1 | KEY REGULATORY POINT IN THE OVERALL SYNTHETIC PATHWAY OF BACTERIAL FATTY ACID BIOSYNTHESIS; FABI IS AN IDEAL TARGET FOR ANTIBACTERIAL INTERVENTION | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-05-04 | — | — | US | disclosed |
| EP-1225894-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1225894-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026652-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |