SCHEMBL5753652

SCHEMBL5753652

COc1cc(F)ccc1OCCN1CCN(CCCC(C#N)(c2ccccc2)C(C)C)CC1

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 3/20 0.56
CYP3A4 P08684 2/20 0.44
LTA4H P09960 1/20 0.42
ABCB1 P08183 2/20 0.41
ALDH1A1 P00352 2/20 0.41
LMNA P02545 2/20 0.41
KDM4E B2RXH2 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPT P10636 1/20 0.41
NLRP1 Q9C000 1/20 0.41
CYP3A5 P20815 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5753172 0.91 CACNA1B (0.47) CACNA1BALDH1A1LMNAKDM4E
SCHEMBL5754627 0.90 CACNA1B (0.46) CACNA1BCYP3A4LTA4HALDH1A1LMNA
SCHEMBL5751383 0.89 CACNA1B (0.48) CACNA1BABCB1LMNAKDM4E
SCHEMBL5749777 0.87 CACNA1B (0.64) CACNA1BCYP3A4ABCB1LMNASMN1; SMN2
SCHEMBL5751449 0.87 KDM4E (0.48) CACNA1BCYP3A4LTA4HALDH1A1LMNA
SCHEMBL5752204 0.86 CACNA1B (0.52) CACNA1BABCB1ALDH1A1KDM4ETDP1
SCHEMBL5753788 0.85 CACNA1G (0.46) CACNA1BALDH1A1KDM4ETDP1
SCHEMBL2866236 0.85 CACNA1B (0.52) CACNA1BLTA4HALDH1A1LMNASMN1; SMN2
SCHEMBL5753351 0.84 CACNA1B (0.52) CACNA1BLTA4HALDH1A1LMNAKDM4E
Hydrochloric Acid SCHEMBL5754015 0.84 CACNA1B (0.53) CACNA1BLTA4HALDH1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1099692-B1 N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES EISAI CO LTD (JP) 2006-05-03 EP claimed
US-6737425-B1 SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS EISAI CO., LTD. (JP) 2004-05-18 US claimed
EP-1099692-A1 N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES Eisai Co., Ltd. (JP) 2001-05-16 EP claimed
EP-1654238-A1 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AMGEN INC. (US) 2006-05-10 EP disclosed
EP-1099692-B1 N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES EISAI CO LTD (JP) 2006-05-03 EP disclosed
WO-2005009978-A1 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AMGEN INC. (US) 2005-02-03 WO disclosed
US-6737425-B1 SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS EISAI CO., LTD. (JP) 2004-05-18 US disclosed
EP-1099692-A1 N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES Eisai Co., Ltd. (JP) 2001-05-16 EP disclosed