Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089595 | 0.71 | PDK2 (0.50) | HRH3CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL4084395 | 0.69 | NFE2L2 (0.54) | HRH3CYP3A4CYP2D6NPSR1MAPK1 | |
| SCHEMBL13792048 | 0.69 | FBP1 (0.43) | HRH3CYP3A4 | |
| SCHEMBL4090609 | 0.68 | MAOB (0.42) | HRH3CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL3989401 | 0.68 | PPARA (0.48) | HRH3CYP3A4LMNA | |
| SCHEMBL1641511 | 0.68 | KDM4E (0.50) | HRH3CYP3A4CYP2D6KDM4E | |
| SCHEMBL1608519 | 0.67 | CA12 (0.50) | KDM4ELMNAL3MBTL1MAPK1MAPT | |
| SCHEMBL7759148 | 0.67 | KDM4E (0.44) | CYP3A4CYP2D6SLC6A2SLC6A4NPSR1 | |
| SCHEMBL30334792 | 0.67 | CA12 (0.50) | KDM4ELMNAL3MBTL1MAPK1MAPT | |
| SCHEMBL4057003 | 0.67 | CA12 (0.50) | NPSR1KDM4ESMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692128-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051942-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2005-06-09 | — | — | WO | disclosed |