Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472087 | 0.81 | ALDH1A1 (0.55) | POLBRECQLPKMMAPTALDH1A1 | |
| SCHEMBL303665 | 0.71 | — | — | |
| SCHEMBL29576607 | 0.71 | — | — | |
| Methylamine SCHEMBL2702693 | 0.69 | HSP90AA1 (0.43) | ALDH1A1KDR | |
| SCHEMBL27411725 | 0.69 | — | — | |
| Bromide SCHEMBL27776140 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL27571277 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL27665874 | 0.69 | HSP90AA1 (0.41) | ALDH1A1KDR | |
| SCHEMBL27841589 | 0.68 | CHEK1 (0.53) | PKMMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL15706871 | 0.65 | MAPT (0.55) | POLBRECQLPKMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716155-A1 | SUBSTITUTED THIENO¬2,3-D|PYRIMIDINES AS INHIBITORS OF TIE2 | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005075483-A1 | SUBSTITUTED THIENO - AND THIAZOLO - [2, 3-D] PYRIDINES AS INHIBITORS OF TIE2 | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |