SCHEMBL5754359

SCHEMBL5754359

O=C(Cn1c(=O)oc2ccc(Cl)cc21)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.80

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 7/20 0.80
CBX7 O95931 4/20 0.54
CDYL Q9Y232 4/20 0.54
CDYL2 Q8N8U2 3/20 0.54
CDY1; CDY1B Q9Y6F8 3/20 0.54
KMO O15229 2/20 0.53
DRD1 P21728 1/20 0.53
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29670895 0.77 KMO (0.74) IDO1KMOKMT2AMEN1
SCHEMBL2953606 0.77 KMO (0.74) IDO1KMOKMT2AMEN1
SCHEMBL16176497 0.76 KMO (0.76) IDO1KMODRD1
SCHEMBL29958110 0.76 IDO1 (0.71) IDO1KMOKMT2AMEN1
SCHEMBL4427326 0.76 IDO1 (0.71) IDO1KMOKMT2AMEN1
SCHEMBL16932344 0.74 IDO1 (0.64) IDO1KMO
SCHEMBL4425116 0.73 KMT2A (0.66) IDO1KMOKMT2AMEN1
SCHEMBL17830728 0.73 ALDH1A1 (0.45) IDO1KMODRD1KMT2AMEN1
SCHEMBL16186523 0.72 IDO1 (0.62) IDO1KMOKMT2AMEN1
Hydrochloric Acid SCHEMBL10544625 0.70 IDO1 (0.61) IDO1KMOKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0915856-A4 DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS BRISTOL MYERS SQUIBB CO (US) 2006-04-12 EP disclosed
US-6271249-B1 Diphenyl imidazoles as potassium channel modulators BRISTOL-MYERS SQUIBB COMPANY 2001-08-07 US disclosed
US-6077861-A MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE BRISTOL-MYERS SQUIBB COMPANY (US) 2000-06-20 US disclosed
EP-0915856-A1 DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS Bristol-Myers Squibb Company (US) 1999-05-19 EP disclosed
US-5869509-A TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-02-09 US disclosed
WO-1998004135-A1 DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-02-05 WO disclosed