Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 15/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367361 | 0.89 | KIF11 (0.46) | KIF11KIF23 | |
| SCHEMBL6795609 | 0.80 | KIF11 (0.48) | KIF11KIF23 | |
| SCHEMBL4364755 | 0.70 | KIF11 (0.68) | KIF11KIF23 | |
| SCHEMBL4367358 | 0.69 | KIF11 (0.51) | KIF11KIF23 | |
| Hydrochloric Acid SCHEMBL4359898 | 0.69 | KIF11 (0.44) | KIF11 | |
| SCHEMBL4376315 | 0.69 | KIF11 (0.53) | KIF11BRD4MEN1KMT2AKIF23 | |
| SCHEMBL5525132 | 0.69 | KIF11 (0.68) | KIF11 | |
| SCHEMBL4375118 | 0.65 | KIF11 (0.68) | KIF11KIF23 | |
| SCHEMBL4362694 | 0.64 | KIF11 (0.68) | KIF11KIF23 | |
| SCHEMBL1887243 | 0.63 | KIF11 (0.51) | KIF11PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |