Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 1/20 | 0.88 |
| ▸ | LTA4H | P09960 | 4/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28218809 | 0.93 | ALDH1A1 (0.77) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL27853338 | 0.92 | HRH3 (0.76) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL28180188 | 0.91 | HRH3 (0.78) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL519633 | 0.87 | LTA4H (0.91) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL4992188 | 0.85 | LTA4H (0.89) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL520019 | 0.84 | LTA4H (0.72) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL27853350 | 0.84 | LTA4H (0.67) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL20236316 | 0.83 | LTA4H (0.71) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL519451 | 0.83 | LTA4H (0.71) | KDM4EALDH1A1TDP1MAPTLTA4H | |
| SCHEMBL28180293 | 0.83 | LTA4H (0.71) | KDM4EALDH1A1TDP1MAPTLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076607-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-107353209-B | There are the two phenoxy group flexible molecules and its preparation method and application of high-affinity with A β plaque block | 北京师范大学 | 2019-07-19 | — | — | CN | disclosed |
| CN-108137518-A | As 6 inhibitor of histone deacetylase 1,3,4- oxadiazole derivatives compound and include its pharmaceutical composition | 株式会社钟根堂 | 2018-06-08 | — | — | CN | disclosed |
| CN-107353209-A | There are two phenoxy group flexible molecules of high-affinity and its preparation method and application with A β plaque block | 北京师范大学 | 2017-11-17 | — | — | CN | disclosed |
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| CN-1310709-A | N, N-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2001-08-29 | — | — | CN | disclosed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-5254689-A | Antiarrhythmia agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |
| US-5202346-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-13 | — | — | US | disclosed |
| US-5147882-A | Cardiovascular disorders | KARL THOMAE GMBH (DE) | 1992-09-15 | — | — | US | disclosed |
| EP-0450429-A1 | Cyclophanes, process for their preparation and pharmaceuticals containing them | Dr. Karl Thomae GmbH (DE) | 1991-10-09 | — | — | EP | disclosed |
| US-4064128-A | SEDATIVES | KALI-CHEMIE AKTIENGESELLSCHAFT (DT) | 1977-12-20 | — | — | US | disclosed |
| US-3969356-A | SEDATIVE, ANALGESIC, ANTIHISTAMINE | KALI-CHEMIE AKTIENGESELLSCHAFT (DT) | 1976-07-13 | — | — | US | disclosed |