Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 16/20 | 0.65 |
| ▸ | PRKCA | P17252 | 16/20 | 0.65 |
| ▸ | GSK3B | P49841 | 13/20 | 0.65 |
| ▸ | PRKCG | P05129 | 12/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.65 |
| ▸ | PRKCH | P24723 | 3/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502731 | 0.83 | GSK3B (0.62) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5754534 | 0.82 | GSK3B (0.76) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3774167 | 0.79 | GSK3B (0.81) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5757856 | 0.79 | GSK3B (1.00) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5757333 | 0.78 | GSK3B (0.85) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5760645 | 0.76 | GSK3B (0.71) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL6069263 | 0.75 | GSK3B (0.61) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5756379 | 0.75 | GSK3B (0.81) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL27520065 | 0.70 | GSK3B (0.61) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5803991 | 0.69 | GSK3B (0.83) | PRKCBPRKCAGSK3BPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |