Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.76 |
| ▸ | PRKCB | P05771 | 14/20 | 0.76 |
| ▸ | PRKCA | P17252 | 14/20 | 0.76 |
| ▸ | PRKCG | P05129 | 12/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.76 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.76 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.76 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3774167 | 0.88 | GSK3B (0.81) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5757856 | 0.86 | GSK3B (1.00) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5760645 | 0.85 | GSK3B (0.71) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5757333 | 0.85 | GSK3B (0.85) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5756379 | 0.84 | GSK3B (0.81) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL13013363 | 0.84 | GSK3B (0.74) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5754543 | 0.82 | PRKCB (0.65) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL6069263 | 0.78 | GSK3B (0.61) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5755363 | 0.77 | GSK3B (0.77) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5803991 | 0.77 | GSK3B (0.83) | GSK3BPRKCBPRKCAPRKCGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1230434-C | Indazolyl-substituted pyrroline compounds as kinase inhibitor | ORTHO MCNEL PHARMACEUTICAL INC (US) | 2005-12-07 | — | — | CN | claimed |
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |