Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750399 | 1.00 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2748535 | 0.93 | STAT3 (0.50) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1265483 | 0.79 | HTR2A (0.43) | ALDH1A1LMNAHTR2AHTR2CJAK2 | |
| SCHEMBL2748266 | 0.79 | HTR2A (0.43) | ALDH1A1LMNAHTR2AHTR2CJAK2 | |
| SCHEMBL2747036 | 0.77 | MCHR1 (0.45) | ALDH1A1HTR2AHTR2CMCHR1 | |
| SCHEMBL5570150 | 0.75 | ALDH1A1 (0.54) | MAPTALDH1A1KMT2ALMNACYP3A4 | |
| SCHEMBL10279 | 0.74 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6815172 | 0.74 | ALDH1A1 (0.45) | MAPTALDH1A1KMT2ALMNANOS3 | |
| SCHEMBL2747373 | 0.73 | MAPT (0.67) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2747371 | 0.73 | MAPT (0.67) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |