Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12076557 | 0.80 | LMNA (0.47) | MAPTCYP3A4ALDH1A1KMT2ALMNA | |
| SCHEMBL2036605 | 0.78 | HTT (0.40) | MAPTCYP3A4MEN1KMT2ALMNA | |
| SCHEMBL5754545 | 0.74 | MAPT (0.47) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL2750399 | 0.74 | MAPT (0.47) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7209 | 0.74 | STAT3 (0.45) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7207 | 0.74 | STAT3 (0.45) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL10797 | 0.74 | ALDH1A1 (0.42) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2027839 | 0.73 | JAK2 (0.42) | MAPTKMT2ALMNANPC1HTT | |
| SCHEMBL2034821 | 0.73 | ELANE (0.43) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL12764522 | 0.73 | TXNRD1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |