Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 8/20 | 0.62 |
| ▸ | RET | P07949 | 12/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759216 | 0.90 | ITK (0.51) | ITKRETKDR | |
| SCHEMBL5754383 | 0.88 | ROCK2 (0.52) | ITKRETKDRINSRCCNE1 | |
| SCHEMBL5756552 | 0.86 | ITK (0.51) | ITKRETINSRCCNE1CDK2 | |
| SCHEMBL5757315 | 0.84 | ITK (0.53) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5759554 | 0.84 | CASP3 (0.58) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5757347 | 0.83 | ITK (0.66) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5759271 | 0.83 | ITK (0.48) | ITKINSRCCNE1CDK2 | |
| SCHEMBL6491253 | 0.83 | ITK (0.50) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5754385 | 0.83 | ITK (0.53) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5754638 | 0.83 | RET (0.45) | ITKRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648884-A2 | PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2006-04-26 | — | — | EP | disclosed |
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
| WO-2005005414-A2 | PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | ITK 392/4885RET 462/4885KDR 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.