Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864333 | 0.80 | PTGS1 (0.49) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL5604490 | 0.80 | KIF11 (0.54) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL5759177 | 0.80 | KIF11 (0.54) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL5756930 | 0.77 | KIF11 (0.63) | MAP1LC3BCYP3A4CYP2C19KIF11KCNH2 | |
| SCHEMBL5754110 | 0.75 | MEN1 (0.40) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL4620734 | 0.71 | KIF11 (0.57) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL5647619 | 0.70 | TDP1 (0.55) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL5649781 | 0.69 | TDP1 (0.51) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL4519529 | 0.68 | KIF11 (0.56) | PTGS1PTGS2TDP1MAPK8MAPK9 | |
| SCHEMBL5648396 | 0.68 | KIF11 (0.56) | PTGS1PTGS2TDP1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556357-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-1556357-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003106426-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-12-24 | — | — | WO | disclosed |