Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754107 | 0.80 | ALDH1A1 (0.41) | MEN1ALDH1A1KMT2APTGS1PTGS2 | |
| SCHEMBL5756188 | 0.78 | KIF11 (0.45) | MEN1ALDH1A1KMT2AKIF11MAP1LC3B | |
| SCHEMBL5752944 | 0.76 | KIF11 (0.38) | MEN1ALDH1A1KMT2AKIF11TDP1 | |
| SCHEMBL5755084 | 0.75 | PTGS1 (0.49) | PTGS1PTGS2KIF11MAP1LC3BCYP3A4 | |
| SCHEMBL4514039 | 0.74 | KIF11 (0.50) | MEN1ALDH1A1KMT2AKIF11MAP1LC3B | |
| SCHEMBL5864327 | 0.73 | CYP2C19 (0.40) | MEN1ALDH1A1KMT2APTGS1PTGS2 | |
| SCHEMBL4424235 | 0.73 | KIF11 (0.47) | MEN1KMT2AKIF11KCNH2MAPK8 | |
| SCHEMBL5758637 | 0.73 | KIF11 (0.41) | ALDH1A1KMT2APTGS1PTGS2KIF11 | |
| SCHEMBL5786959 | 0.73 | L3MBTL1 (0.37) | ALDH1A1PTGS1PTGS2KIF11MAP1LC3B | |
| SCHEMBL5863996 | 0.72 | ALDH1A1 (0.39) | MEN1ALDH1A1KMT2ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556357-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-1556357-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003106426-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-12-24 | — | — | WO | disclosed |