Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753186 | 0.89 | PIN1 (0.45) | PIK3CAPIK3CBPIK3CGL3MBTL1PIN1 | |
| SCHEMBL14461134 | 0.87 | PIN1 (0.40) | PIK3CAPIK3CBPIK3CGL3MBTL1PIN1 | |
| SCHEMBL5755610 | 0.86 | MEN1 (0.47) | PIK3CAPIK3CBPIK3CGL3MBTL1PIN1 | |
| SCHEMBL12264711 | 0.82 | NQO2 (0.41) | PIK3CAPIK3CBPIK3CGL3MBTL1PIN1 | |
| SCHEMBL12264712 | 0.82 | PIN1 (0.40) | PIK3CAPIK3CBPIK3CGL3MBTL1PIN1 | |
| SCHEMBL5754880 | 0.79 | ALDH1A1 (0.38) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5756395 | 0.77 | HDAC3 (0.40) | PIN1MEN1KMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL5755645 | 0.77 | KMT2A (0.40) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL5753538 | 0.74 | MAPT (0.44) | MEN1KMT2ASMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL5754027 | 0.74 | MEN1 (0.49) | PIK3CAPIK3CBPIK3CGL3MBTL1PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218358-B1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| EP-1218358-A1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| US-6399603-B1 | QUINAZOLINES; RETARDING APOPTOSIS IN CELLS; INHIBITING CLEAVAGE OF PROTEIN SUBSTRATES BY CASPASE-3; CHEMICAL AND HYDROLYTIC STABILITY | ASTRAZENECA AB (SE) | 2002-06-04 | — | — | US | disclosed |
| WO-2001021598-A1 | THERAPEUTIC QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |