Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440292 | 0.85 | HPGD (0.51) | HPGDLMNAHTTPOLBMEN1 | |
| SCHEMBL4025171 | 0.85 | LMNA (0.48) | HPGDLMNAHTTPOLBMEN1 | |
| SCHEMBL5757324 | 0.82 | ELANE (0.55) | ELANEPOLBKMT2A | |
| SCHEMBL5759586 | 0.81 | ELANE (0.63) | ELANEKMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5758307 | 0.81 | KMT2A (0.58) | ELANEHPGDLMNAPOLBMAPT | |
| SCHEMBL5755732 | 0.81 | KMT2A (0.58) | ELANEHPGDLMNAPOLBMAPT | |
| SCHEMBL5760188 | 0.80 | ELANE (0.55) | ELANEHPGDLMNAHTTPOLB | |
| SCHEMBL5759188 | 0.79 | ELANE (0.60) | ELANEALDH1A1NPC1RAB9A | |
| SCHEMBL5758001 | 0.77 | ELANE (0.68) | ELANEHPGDLMNAHTTMEN1 | |
| SCHEMBL5758008 | 0.77 | ELANE (0.68) | ELANEHPGDLMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325003-B1 | 7-CHLORO-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINO 4,5-B|QUINOLINE-1,10-DIONE AND THE USE THEREOF FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| EP-1325002-B1 | 1,2,5,10-TETRAHYDROPYRIDAZINO¬4,5-B|QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-05-24 | — | — | EP | disclosed |
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| EP-1244660-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| US-20060035938-A1 | 2-Pyridone derivatives as inhibitors of neutrophile elastase | ASRAZENECA AB (SE) | 2006-02-16 | — | — | US | disclosed |
| EP-1577311-A1 | Salts of a pyridazino aquinoline derivative and use for the treatment of pain | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| US-6946463-B2 | 1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain | ASTRAZENECA AB (SE) | 2005-09-20 | — | — | US | disclosed |
| US-6943165-B2 | Compound and method for the treatment of pain | ASTRAZENECA AB (SE) | 2005-09-13 | — | — | US | disclosed |
| US-6933297-B2 | 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain | ASTRAZENECA AB (CH) | 2005-08-23 | — | — | US | disclosed |
| US-20050124622-A1 | Compounds and methods for the treatment of pain | BROWN DEAN G (US) | 2005-06-09 | — | — | US | disclosed |
| US-6214826-B1 | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 2001-04-10 | — | — | US | disclosed |
| EP-0724583-B1 | PYRIDAZINO QUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| EP-1004582-A2 | Pyridazino quinoline compounds | AstraZeneca UK Limited (GB) | 2000-05-31 | — | — | EP | disclosed |
| US-5837705-A | AN ANTAGONIST OF EXCITATORY AMINO ACID AND GLYCINE RECEPTOR FOR TREATING NEURODEGENERATIVE DISORDER, STROKE, HYPOGLYCEMIA, ISCHEMIC ATTACK, ANOXIA OR EPILEPSY | ZENECA LIMITED (GB) | 1998-11-17 | — | — | US | disclosed |
| US-5744471-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1998-04-28 | — | — | US | disclosed |
| EP-0790996-A1 | PYRIDAZINOQUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| EP-0736531-A1 | Alpha-substituted pyridazino quinoline compounds | ZENECA LIMITED (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0724583-A1 | PYRIDAZINO QUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1996015127-A1 | PYRIDAZINOQUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |
| WO-1995011244-A1 | PYRIDAZINO QUINOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1995-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035938-A1 | 2-Pyridone derivatives as inhibitors of neutrophile elastase | SERPINB1, ELANE, SERPINE1 | ELANE 2/4885HPGD 170/4885LMNA 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.