Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 5/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754226 | 0.89 | SULT1A1 (0.48) | CA2APPGLAGAASULT1A1 | |
| SCHEMBL5756650 | 0.87 | CA2 (0.60) | CA2NPC1RAB9AMEN1MAPT | |
| SCHEMBL5756092 | 0.84 | SULT1A1 (0.50) | APPGLAGAASULT1A1ALK | |
| SCHEMBL5754836 | 0.81 | KDM4E (0.54) | APPGAASULT1A1ALKHSD17B1 | |
| SCHEMBL5761063 | 0.79 | NPC1 (0.53) | APPGLAGAASULT1A1ALK | |
| SCHEMBL5757681 | 0.79 | APP (0.47) | APPSULT1A1ALKNPC1HTT | |
| SCHEMBL4287939 | 0.78 | APP (0.67) | APPGLAGAASULT1A1ALK | |
| SCHEMBL5761015 | 0.78 | CA2 (0.48) | CA2APPGAANPC1RAB9A | |
| SCHEMBL5757275 | 0.77 | SULT1A1 (0.47) | APPSULT1A1ALKHSD17B1HSD17B2 | |
| SCHEMBL5981201 | 0.76 | MAPT (0.71) | APPGLAGAASULT1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539723-B1 | NOVEL USE OF BENZOTHIAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-24 | — | — | EP | claimed |