Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 7/20 | 0.48 |
| ▸ | CCND1 | P24385 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445121 | 0.81 | MAPT (0.61) | HDAC1HDAC6IGF1RMETCDK4 | |
| SCHEMBL5760400 | 0.78 | PDGFRB (0.55) | HDAC1HDAC6MEN1NPC1RAB9A | |
| SCHEMBL27649282 | 0.77 | GBA1 (0.46) | HDAC1HDAC6RAB9ABCHEACHE | |
| SCHEMBL27275913 | 0.75 | CDK4 (0.58) | CDK4CCND1 | |
| SCHEMBL445847 | 0.72 | HDAC1 (0.57) | HDAC1HDAC6CDK4CCND1MAPT | |
| SCHEMBL4251688 | 0.72 | MAPT (0.58) | HDAC1HDAC6MAPTSMN1; SMN2MEN1 | |
| SCHEMBL13763424 | 0.72 | PBRM1 (0.58) | CDK4CCND1SMN1; SMN2KMT2ATP53 | |
| SCHEMBL9036635 | 0.72 | CDK4 (0.43) | CDK4CCND1MEN1NPC1KMT2A | |
| SCHEMBL10648144 | 0.72 | SMN1; SMN2 (0.69) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL9688745 | 0.71 | CDK4 (0.45) | CDK4CCND1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006042035-A2 | METHOD OF MONITORING ANTI-TUMOR ACTIVITY OF AN HDAC INHIBITOR | PHARMACYCLICS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | disclosed |