Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.43 |
| ▸ | CCND1 | P24385 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038237 | 0.84 | CDK4 (0.41) | CDK4CCND1CDK2HTR2CKDR | |
| SCHEMBL9037383 | 0.82 | HTR2C (0.41) | CDK4CCND1CDK2HTR2CKDR | |
| SCHEMBL9036372 | 0.82 | HTR2C (0.41) | CDK4CCND1CDK2HTR2CKDR | |
| SCHEMBL9038031 | 0.81 | HTR2C (0.41) | CDK4CCND1CDK2HTR2CKDR | |
| SCHEMBL9688745 | 0.81 | CDK4 (0.45) | CDK4CCND1CDK2HTR2CNR4A2 | |
| SCHEMBL9038843 | 0.77 | LMNA (0.39) | CDK4CCND1CDK2HTR2CKDR | |
| SCHEMBL9038042 | 0.73 | KDR (0.46) | CDK4CCND1HTR2CKDRLMNA | |
| SCHEMBL9037086 | 0.73 | CDK4 (0.42) | CDK4CCND1CDK2HTR2CKDR | |
| SCHEMBL9037640 | 0.73 | KDR (0.43) | CDK4CCND1KDRKMT2A | |
| SCHEMBL5757545 | 0.72 | HDAC1 (0.51) | CDK4CCND1MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507861-B1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS | UPJOHN CO (US) | 1996-09-11 | — | — | EP | claimed |
| WO-1991009849-A1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | claimed |