Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.85 |
| ▸ | MMP1 | P03956 | 17/20 | 0.85 |
| ▸ | MMP13 | P45452 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757764 | 0.92 | ADAM17 (1.00) | ADAM17MMP1MMP13 | |
| SCHEMBL5758329 | 0.91 | ADAM17 (1.00) | ADAM17MMP1MMP13 | |
| SCHEMBL27573345 | 0.89 | ADAM17 (0.68) | ADAM17MMP1MMP13 | |
| SCHEMBL5760037 | 0.89 | ADAM17 (0.85) | ADAM17MMP1MMP13 | |
| SCHEMBL7055515 | 0.88 | MMP1 (0.67) | ADAM17MMP1MMP13 | |
| SCHEMBL5807852 | 0.88 | ADAM17 (0.80) | ADAM17MMP1MMP13 | |
| SCHEMBL5757353 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13 | |
| SCHEMBL5759927 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13 | |
| SCHEMBL5760087 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13 | |
| SCHEMBL5756114 | 0.86 | ADAM17 (0.80) | ADAM17MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-B1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PROD INC (US) | 2006-05-10 | — | — | EP | disclosed |
| US-6329397-B1 | TREATMENT OF A CONDITION SELECTED FROM THE GROUP CONSISTING OF ARTHRITIS, CANCER, AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE OR MAMMALIAN REPROLYSIN ACTIVITY. | PFIZER | 2001-12-11 | — | — | US | disclosed |
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |