Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756174 | 0.84 | OPRM1 (0.53) | HTR1AOPRM1OPRK1KCNH2TSHR | |
| SCHEMBL5793250 | 0.83 | OPRM1 (0.44) | HTR1AOPRM1OPRK1KCNH2TSHR | |
| SCHEMBL5754560 | 0.83 | OPRM1 (0.44) | HTR1AOPRM1OPRK1KCNH2OPRD1 | |
| SCHEMBL5757776 | 0.81 | OPRM1 (0.46) | HTR1AOPRM1OPRK1KCNH2OPRD1 | |
| SCHEMBL5753440 | 0.77 | OPRM1 (0.57) | HTR1AOPRM1OPRK1KCNH2HTR7 | |
| SCHEMBL5753956 | 0.76 | OPRM1 (0.51) | OPRM1OPRK1KCNH2OPRD1 | |
| SCHEMBL5756507 | 0.76 | OPRM1 (0.43) | OPRM1OPRK1KCNH2OPRD1UBE2M | |
| SCHEMBL5753952 | 0.75 | OPRM1 (0.40) | OPRM1OPRK1KCNH2OPRD1 | |
| SCHEMBL6654876 | 0.74 | OPRM1 (0.73) | OPRM1OPRK1OPRD1 | |
| SCHEMBL6654874 | 0.74 | OPRM1 (0.73) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140828-B1 | 3-AZABICYCLO¬3.1.0|HEXANE DERIVATIVES AS OPIATE RECEPTORS LIGANDS | PFIZER LTD (GB) | 2006-08-09 | — | — | EP | claimed |