Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793250 | 0.90 | OPRM1 (0.44) | OPRM1OPRD1OPRK1KCNH2DRD3 | |
| SCHEMBL5753956 | 0.89 | OPRM1 (0.51) | OPRM1OPRD1OPRK1KCNH2DRD3 | |
| SCHEMBL5756507 | 0.84 | OPRM1 (0.43) | OPRM1OPRD1OPRK1KCNH2LMNA | |
| SCHEMBL5756174 | 0.78 | OPRM1 (0.53) | OPRM1OPRD1OPRK1KCNH2DRD3 | |
| SCHEMBL5754560 | 0.75 | OPRM1 (0.44) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5757774 | 0.75 | HTR1A (0.44) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5757776 | 0.73 | OPRM1 (0.46) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5751494 | 0.71 | OPRM1 (0.58) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5753651 | 0.70 | OPRM1 (0.61) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5753749 | 0.70 | OPRM1 (0.74) | OPRM1OPRD1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140828-B1 | 3-AZABICYCLO¬3.1.0|HEXANE DERIVATIVES AS OPIATE RECEPTORS LIGANDS | PFIZER LTD (GB) | 2006-08-09 | — | — | EP | claimed |