Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.64 |
| ▸ | PRKCB | P05771 | 14/20 | 0.64 |
| ▸ | PRKCA | P17252 | 14/20 | 0.64 |
| ▸ | PRKCG | P05129 | 13/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.64 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766535 | 0.81 | GSK3B (0.64) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL13013272 | 0.78 | GSK3B (1.00) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3784374 | 0.77 | PRKCA (0.76) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5757325 | 0.75 | GSK3B (0.83) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5754128 | 0.75 | PRKCA (0.85) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5757880 | 0.75 | PRKCA (0.85) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3774124 | 0.74 | PRKCA (1.00) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL2985115 | 0.74 | GSK3B (0.82) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL13013368 | 0.72 | GSK3B (0.88) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5759641 | 0.72 | PRKCA (0.95) | GSK3BPRKCBPRKCAPRKCGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |