Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.57 |
| ▸ | PRKACG | P22612 | 2/20 | 0.57 |
| ▸ | PRKACB | P22694 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | QPCT | Q16769 | 4/20 | 0.51 |
| ▸ | PRKCB | P05771 | 3/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.49 |
| ▸ | PRKCG | P05129 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758099 | 0.87 | GSK3B (0.67) | GSK3BPRKACAPRKACGPRKACBKDR | |
| SCHEMBL5756212 | 0.80 | GSK3B (0.56) | GSK3BKDRQPCTPRKCBPRKCA | |
| SCHEMBL5758425 | 0.79 | GSK3B (0.58) | GSK3BPRKACAPRKACGPRKACBKDR | |
| SCHEMBL9087475 | 0.77 | PRKACA (0.82) | GSK3BPRKACAPRKACGPRKACBQPCT | |
| SCHEMBL5758142 | 0.77 | GSK3B (0.72) | GSK3BPRKACAPRKACGPRKACBKDR | |
| SCHEMBL9087381 | 0.75 | PRKACA (0.82) | GSK3BPRKACAPRKACGPRKACBKDR | |
| SCHEMBL5759256 | 0.75 | GSK3B (0.69) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL4676092 | 0.75 | GSK3B (0.58) | GSK3BPRKACAPRKACGPRKACBKDR | |
| SCHEMBL9085155 | 0.74 | PRKACA (0.71) | GSK3BPRKACAPRKACGPRKACBKDR | |
| SCHEMBL7824089 | 0.73 | PRKACA (1.00) | GSK3BPRKACAPRKACGPRKACBQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |