Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.58 |
| ▸ | PRKCB | P05771 | 4/20 | 0.58 |
| ▸ | PRKCA | P17252 | 4/20 | 0.58 |
| ▸ | PRKCG | P05129 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 3/20 | 0.52 |
| ▸ | QPCT | Q16769 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756212 | 0.94 | GSK3B (0.56) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5758099 | 0.92 | GSK3B (0.67) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5754325 | 0.85 | GSK3B (0.69) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL4680373 | 0.80 | GSK3B (0.60) | GSK3BPRKCBPRKCAKDRQPCT | |
| SCHEMBL5758352 | 0.79 | GSK3B (0.58) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5754334 | 0.79 | GSK3B (0.67) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5759256 | 0.77 | GSK3B (0.69) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5758142 | 0.77 | GSK3B (0.72) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3779533 | 0.76 | PRKCA (0.64) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5755163 | 0.74 | GSK3B (1.00) | GSK3BPRKCBPRKCAPRKCGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |