Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768815 | 0.88 | PIM1 (0.48) | MAOBCHEK2ALDH1A1MEN1KMT2A | |
| SCHEMBL5760224 | 0.86 | HPGD (0.48) | MAOBCHEK2TAS1R3TAS1R1MAPT | |
| SCHEMBL4764679 | 0.85 | CHEK2 (0.49) | MAOBCHEK2ALDH1A1MEN1KMT2A | |
| SCHEMBL8902416 | 0.79 | MAPT (0.57) | CHEK2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL445130 | 0.79 | KDM4E (0.55) | MAOBALDH1A1MAOAKDM4E | |
| SCHEMBL9989067 | 0.79 | MAOB (0.55) | MAOBALDH1A1MEN1KMT2AMAOA | |
| Hydrochloric Acid SCHEMBL5970288 | 0.77 | CHEK2 (0.40) | CHEK2TAS1R3TAS1R1HPGD | |
| SCHEMBL6560708 | 0.76 | MAPT (0.56) | CHEK2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5105919 | 0.75 | CYP1A2 (0.61) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6386675 | 0.74 | XDH (0.52) | MAOBALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006042035-A2 | METHOD OF MONITORING ANTI-TUMOR ACTIVITY OF AN HDAC INHIBITOR | PHARMACYCLICS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | disclosed |