Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.46 |
| ▸ | PGR | P06401 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | IL6 | P05231 | 1/20 | 0.40 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | GLUL | P15104 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5943274 | 0.86 | KDM4E (0.80) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL5943277 | 0.86 | KDM4E (0.80) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL5758833 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL5935168 | 0.85 | KDM4E (0.56) | KDM4EHIF1APGRLMNACYP3A4 | |
| SCHEMBL5757332 | 0.85 | KDM4E (0.56) | KDM4EHIF1APGRLMNACYP3A4 | |
| SCHEMBL15167259 | 0.85 | KDM4E (0.56) | KDM4EHIF1APGRLMNACYP3A4 | |
| SCHEMBL5757425 | 0.84 | KDM4E (0.51) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL3170735 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL3170744 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL5259047 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1MAPK1HIF1APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252926-A1 | Process for the preparation of pregnanes | SICOR, INC. | 2006-11-09 | — | — | US | disclosed |
| EP-1474435-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA FLUORINATED PREGNANES | SICOR INC (US) | 2006-02-22 | — | — | EP | disclosed |
| EP-1474435-A1 | PROCESS FOR THE PREPARATION OF PREGNANES | Sicor Inc. (US) | 2004-11-10 | — | — | EP | disclosed |
| WO-2004052911-A1 | PROCESS FOR THE PREPARATION OF PREGNANES | SICOR INC. (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252926-A1 | Process for the preparation of pregnanes | CYP17A1, CYP21A2, NR5A1 | KDM4E 4594/4885ALDH1A1 1775/4885MAPK1 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.