Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29061683 | 0.82 | MAP4K4 (0.60) | NR4A2NCF1PIK3CDPIK3CGPI4KA | |
| SCHEMBL4151090 | 0.82 | MAP4K4 (0.60) | NR4A2NCF1PIK3CDPIK3CGPI4KA | |
| SCHEMBL16459814 | 0.78 | NR4A2 (0.55) | NR4A2NCF1PIK3CDPIK3CGMAPT | |
| SCHEMBL4823097 | 0.75 | NR4A2 (0.66) | NR4A2NCF1PIK3CDPIK3CGMAPT | |
| SCHEMBL30210360 | 0.75 | NR4A2 (0.66) | NR4A2NCF1PIK3CDPIK3CGMAPT | |
| SCHEMBL12281648 | 0.74 | DYRK1B (0.73) | MAP4K4DYRK1A | |
| SCHEMBL4154078 | 0.73 | NR4A2 (0.50) | NR4A2NCF1PIK3CDPIK3CGMAPT | |
| SCHEMBL4155195 | 0.73 | NR4A2 (0.54) | NR4A2NCF1PIK3CDPIK3CGSOS2 | |
| SCHEMBL4146183 | 0.73 | NR4A2 (0.50) | NR4A2NCF1PIK3CDPIK3CGSOS2 | |
| SCHEMBL24151244 | 0.73 | TGFBR1 (0.53) | NR4A2NCF1PIK3CDPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |