Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.59 |
| ▸ | NCF1 | P14598 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29061683 | 1.00 | MAP4K4 (0.60) | MAP4K4PIK3CANCF1NR4A2MAPKAPK2 | |
| SCHEMBL15138972 | 0.86 | NCF1 (0.58) | MAP4K4PIK3CANCF1NR4A2ALK | |
| SCHEMBL5758549 | 0.82 | NR4A2 (0.56) | MAP4K4PIK3CANCF1NR4A2PI4KA | |
| SCHEMBL4146183 | 0.80 | NR4A2 (0.50) | MAP4K4PIK3CANCF1NR4A2MAPKAPK2 | |
| SCHEMBL4155195 | 0.80 | NR4A2 (0.54) | MAP4K4PIK3CANCF1NR4A2MAPKAPK2 | |
| SCHEMBL9709110 | 0.80 | PIK3CA (0.87) | MAP4K4PIK3CAMAPKAPK2ALKJAK2 | |
| SCHEMBL27916529 | 0.80 | SLC22A12 (0.52) | MAP4K4NCF1NR4A2MAPKAPK2EGFR | |
| SCHEMBL25402740 | 0.79 | PIK3CA (0.59) | MAP4K4PIK3CAMAPKAPK2ALKPLG | |
| SCHEMBL28723682 | 0.79 | PIK3CA (0.59) | MAP4K4PIK3CAMAPKAPK2ALKPLG | |
| SCHEMBL31121065 | 0.79 | PIK3CA (0.59) | MAP4K4PIK3CAMAPKAPK2ALKPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069338-A1 | Method for predicting skin sensitizing activity of compounds | DICKSON JR JOHN K | 2009-03-12 | — | — | US | disclosed |
| US-7452887-B2 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AMPHORA DISCOVERY CORPORATION (US) | 2008-11-18 | — | — | US | disclosed |
| US-20060009460-A1 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AGRIUS GROUP, LLC. | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069338-A1 | Method for predicting skin sensitizing activity of compounds | ATP5ME, ABCG2, ATP5MG | MAP4K4 1842/4885PIK3CA 1069/4885NCF1 672/4885 |
| US-20060009460-A1 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | ATP5ME, ATP5MG, ATP5MK | MAP4K4 1968/4885PIK3CA 536/4885NCF1 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.